Get to know Dr. Machin
My research focuses on cardiovascular physiology and the influence of aging and lifestyle on the development of cardiovascular disease. There are a number of age- and lifestyle-related changes in the structural and functional properties of arteries that result in impaired vascular function, elevated blood pressure, and contribute to cardiovascular disease risk. I study the effects of intervention, particularly exercise and dietary, on restoration of vascular function and reductions in blood pressure. Additionally, I study physiological and molecular mechanisms responsible for changes in vascular function and blood pressure with aging and following intervention.
- BS – Physical Education (William Paterson University, Wayne, NJ)
- MS – Exercise Physiology (University of Texas at Austin, Austin, TX)
- PhD – Exercise Physiology (University of Texas at Austin, Austin, TX)
- Postdoctoral Training (University of Utah School of Medicine, Salt Lake City, UT)
Publications and Other Scholarly Activities
For a complete list see Google Scholar
Machin DR, Auduong Y, Gogulamudi VR, Liu Y, Islam MT, Lesniewski LA, Donato AJ. Lifelong SIRT-1 overexpression attenuates large artery stiffening with advancing age. Aging. 12(12): 11314-11324, 2020. PMID: 32564006. PMCID: PMC7343505.
Machin DR, Phuong TT, Donato AJ. The role of the endothelial glycocalyx in advanced age and cardiovascular disease. Curr Opin Pharmacol. 45: 66-71, 2019. PMID: 31112922. PMCID: PMC7055464.
Walker AE, Breevoort SR, Durrant JR, Machin DR, Dobson PS, Nielson EI, Meza A, Islam MT, Donato AJ, Lesniewski LA. A western diet, but not aging, exacerbates the pro-atherogenic response to disturbed blood flow. Sci Rep. 9(1): 2925, 2019. PMID: 30814657. PMCID: PMC6393500.
Morgan RG, Walker AE, Trott DW, Machin DR, Henson GD, Reihl KD, Cawthon RM, Denchi EL, Liu Y, Bloom SI, Phuong TT, Richardson RS, Lesniewski LA, Donato AJ. Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress. J Mol Cell Cardiol. 127: 74-82, 2019. PMID: 30502348. PMCID: PMC7216296.
Frech TM, Machin DR, Murtaugh MA, Stoddard GJ, Bloom SI, Phibbs JV, Donato AJ. Implications of endothelial shear stress on systemic sclerosis vasculopathy and treatment. Clin Exp Rheumatol. 36 Suppl(4): 175-182, 2018. PMID 30277867. PMCID: PMC6542469.
Donato AJ, Machin DR, Lesniewski LA. Mechanisms of dysfunction in the aging vasculature and role in age-related disease. Circ Res. 123(7): 825-848, 2018. PMID: 30355078. PMCID: PMC6207260.
Clifton HL, Machin DR, Groot HJ, Frech TM, Donato AJ, Richardson RS, Wray DW. Attenuated nitric oxide bioavailability in patients with systemic sclerosis: Evidence from the novel assessment of passive leg movement. Exp Physiol. 103: 1412-1424, 2018. PMID: 29790215. PMCID: PMC6167160.
Machin DR, Bloom SI, Campbell RA, Phuong TTT, Gates PE, Lesniewski LA, Rondina MT, Donato AJ. Advanced age results in a diminished endothelial glycocalyx. Am J Physiol Heart Circ Physiol. 315(3): H531-H539, 2018. PMID: 29750566. PMCID: PMC6172638.
Machin DR, Gates PE, Vink H, Frech TM, Donato AJ. Automated measurement of microvascular function reveals dysfunction in systemic sclerosis: a cross-sectional study. J Rheumatol. 44(11): 1603-1611, 2017. PMID: 28916547. PMCID: PMC5668162.
Machin DR, Clifton HL, Richardson RS, Wray DW, Donato AJ, Frech TM. Acute oral tetrahydrobiopterin administration ameliorates endothelial dysfunction in systemic sclerosis. Clin Exp Rheumatol. 35(Suppl 106): 167-172, 2017. PMID: 28980911. PMCID: PMC5644995.
Machin DR, Clifton HL, Garten RS, Gifford JR, Richardson RS, Wray DW, Frech TM, Donato AJ. Exercise-induced brachial artery blood flow and vascular function is impaired in systemic sclerosis. Am J Physiol Heart Circ Physiol. 311: H1375-H1381, 2016. PMID: 27694218. PMCID: PMC5206341.
Machin DR, Leary ME, He Y, Shiu Y, Tanaka H, Donato AJ. Ultrasound assessment of flow-mediated dilation of the brachial and superficial femoral arteries in rats. J Vis Exp. 117: e65762, 2016. PMID: 27842366. PMCID: PMC5226081.
2020 Young Investigator Award by American Physiological Society Cardiovascular Section Clinical Science at Experimental Biology annual meeting, San Diego, CA
2019 Loan Repayment Grant Recipient by National Institute of Health, Bethesda, MD
2016 Postdoctoral Research Award by American Physiological Society Environmental and Exercise Physiology Section at Experimental Biology annual meeting, San Diego, CA
2016 Loan Repayment Grant Recipient by National Institute of Health, Bethesda, MD
2015 Research Recognition Award by American Physiological Society Cardiovascular Section at Experimental Biology annual meeting, Boston, MA