Machin Lab

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Our lab research focuses on cardiovascular physiology and the influence of aging and lifestyle on the development of cardiovascular disease. There are a number of age- and lifestyle-related changes in the structural and functional properties of arteries that result in impaired vascular function, elevated blood pressure, and contribute to cardiovascular disease risk. I study the effects of intervention, particularly exercise and dietary, on restoration of vascular function and reductions in blood pressure. Additionally, I study physiological and molecular mechanisms responsible for changes in vascular function and blood pressure with aging and following intervention.

Dan Machin, Ph.D.
Assistant Professor | Lab Director

Ph.D. Candidate | Lab Assistant
Exercise Physiology

Ph.D. Candidate | Lab Assistant
Exercise Physiology

Ph.D. Candidate | Lab Assistant
Exercise Physiology

Sirt1 overexpression attenuates Western‐style diet‐induced aortic stiffening in mice

VR Gogulamudi, DR Machin, GD Henson, J Lim, RC Bramwell, …
Physiological Reports 10 (9), e15284
Microcirculatory and glycocalyx properties are lowered by high-salt diet but augmented by Western diet in genetically heterogeneous mice

X Zheng, C Deacon, AJ King, DR Machin
American Journal of Physiology-Heart and Circulatory Physiology 322 (2 …
Tetrahydrobiopterin Administration Augments Exercise-Induced Hyperemia and Endothelial Function in Patients With Systemic Sclerosis

DR Machin, HL Clifton, DW Wray, TM Frech, AJ Donato
Frontiers in Medicine 8, 791689
T cells mediate cell non‐autonomous arterial ageing in mice

DW Trott, DR Machin, TTT Phuong, ALO Adeyemo, SI Bloom, …
The Journal of Physiology 599 (16), 3973-3991
Aging differentially impacts vasodilation and angiogenesis in arteries from the white and brown adipose tissues

MT Islam, GD Henson, DR Machin, RC Bramwell, AJ Donato, …
Experimental gerontology 142, 111126
Lifelong SIRT-1 overexpression attenuates large artery stiffening with advancing age

DR Machin, Y Auduong, VR Gogulamudi, Y Liu, MT Islam, LA Lesniewski, …
Aging (Albany NY) 12 (12), 11314